Read papers from the keyword phosphatidylserine, multiple sclerosis with Read by QxMD. Eleven patients (29%) had aPL, with various phospholipid specificities. We show here that patients with concurrent natural helminth infections and MS condition (HIMS) had an increased expression of the negative regulatory TAM receptors in antigen-presenting cells and their agonist GAS6 in circulating CD11bhigh and CD4+ T cells compared to patients with only MS... https://read.qxmd.com/read/32401602/cybb-nox2-in-conventional-dcs-controls-t-cell-encephalitogenicity-during-neuroinflammation, Christian W Keller, Monika B Kotur, Sarah Mundt, Nikolaos Dokalis, Laure-Anne Ligeon, Ajay M Shah, Marco Prinz, Burkhard Becher, Christian Münz, Jan D Lünemann. While FTY720-induced cytotoxicity is not due to S1PR signaling, the mechanism remains unclear and is reported to occur through various cell death pathways. The measurement of the phospholipid content (mainly phosphatidylserine; PSer) of microparticles and the detection of proteins specific for the cells from which they are derived has allowed their quantification and characterization. The possibility of engineering the immune system in a targeted fashion using biomaterials such as nanoparticles has made considerable headway in recent years. Mitoxantrone-induced suicidal erythrocyte death. Antiphospholipid antibodies (aPL) comprise a heterogeneous group of autoantibodies. Phosphatidylserine (PS) is found in some specific foods and is also marketed in dietary supplement form. She was old, and her health was not what it used to be, but to see her happy and not scared anymore, just made it worth it! Myelin alters the inflammatory phenotype of macrophages by activating PPARs. Results of antibodies against phosphatidylserine were found similar to CL, but antibodies against phosphatidylcholine were in most cases negative. Phosphatidylserine has effect on scavenging free radicals, anti-oxidation. Increasing acetyl-CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis. Antiphospholipid syndrome is considered to be a cause of an acquired hypercoagulable state leading to stroke and transient ischemic attack. diabetic AND foot The search for aPL directed against 4 phospholipids (cardiolipin, phosphatidylserine, inositol, ethanolamine) was by ELISA. There is circumstantial evidence that proinflammatory cytokines like tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) could have disease-promoting roles in multiple sclerosis (MS). eHealthMe is studying from 4,022 Amyotrophic lateral sclerosis patients now. The fatty acid composition of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin and phosphatidylinositol phospholipids in the peripheral blood mononuclear cells of twenty-six multiple sclerosis and twenty-five control subjects were measured by GC, and C-reactive protein was measured in all subjects. In mammals, phosphatidylserine is produced by base-exchange reactions with phosphatidylcholine and phosphatidylethanolamine. Search for cellular stress biomarkers in lymphocytes from patients with multiple sclerosis: a pilot study. Semaphorin4A Is Cytotoxic to Oligodendrocytes and Is Elevated in Microglia and Multiple Sclerosis. In this report we show that geometric manipulation of phosphatidylserine (PS) through fabrication on rod-shaped PLGA nanoparticles robustly dampens inflammatory responses from innate immune cells while promoting T regulatory cell abundance by impeding effector T cell expansion... https://read.qxmd.com/read/26024919/semaphorin4a-is-cytotoxic-to-oligodendrocytes-and-is-elevated-in-microglia-and-multiple-sclerosis, Dominique F Leitner, Bozho Todorich, Xuesheng Zhang, James R Connor. Amyotrophic lateral sclerosis (nervous system disease that attacks nerve cells called neurons in your brain and spinal cord) has been reported by people with rheumatoid arthritis, high blood cholesterol, multiple sclerosis, hyperlipidaemia, high blood pressure. Genetic ablation of this pathway impairs presentation of myelin-associated antigen following phagocytosis of injured, phosphatidylserine-exposing oligodendroglial cells... https://read.qxmd.com/read/29318974/understanding-the-role-of-hypoxia-inducible-factor-during-neurodegeneration-for-new-therapeutics-opportunities, Amalia Merelli, Julio César García Rodríguez, Jaume Folch, Marcelo R Regueiro, Antoni Camins, Alberto Lazarowski. Role of lipid interactions in autoimmune demyelination. Aim: Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. However, the mode(s) of action of reactive microglia in causing synaptic defects are not fully understood. Phosphatidylserine‐exposed neurons are normally recognised either via the opsonin Gas6 and MerTK/Axl receptors on microglia ... ‘Demyelination’ refers to loss of myelin in a variety of pathologies, such as multiple sclerosis. An understanding of the structure and composition of the myelin sheath is essential to understand the pathogenesis of demyelinating diseases such as multiple sclerosis (MS). The exposure of phosphatidylserine (PS) on the outer plasma membrane has long been considered a unique feature of apoptotic cells. Liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis. Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Stress. Recent evidence indicates synaptic dysfunction as an early mechanism affected in neuroinflammatory diseases, such as multiple sclerosis, which are characterized by chronic microglia activation. Multiple sclerosis (MS) is a highly disabling neurodegenerative autoimmune condition in which an unbalanced immune response plays a critical role. Kinetics of human peptidylarginine deiminase 2 (hPAD2)--reduction of Ca2+ dependence by phospholipids and assessment of proposed inhibition by paclitaxel side chains. It is predominantly expressed in the T-cells and localized in the center of immunological synapse upon T-cell receptor (TCR) and CD28 signaling. Although protein interactions are involved in maintaining normal myelin structure, we describe here how lipids contribute to myelin stability and how lipid changes in EAE, including increases in lipid polyunsaturation and negatively charged phosphatidylserine (PS), promote demyelination... https://read.qxmd.com/read/14592460/adhesion-and-clustering-of-charge-isomers-of-myelin-basic-protein-at-model-myelin-membranes, L V Shanshiashvili, N Ch Suknidze, G G Machaidze, D G Mikeladze, J J Ramsden. Antiphospholipid antibodies in multiple sclerosis first met the left fourth finger association between autoreactive antibodies in multiple sclerosis (... 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